Brain‐derived neurotrophic factor gene polymorphisms in Japanese patients with sporadic Alzheimer's disease, Parkinson's disease, and multiple system atrophy
Identifieur interne : 003999 ( Main/Exploration ); précédent : 003998; suivant : 003A00Brain‐derived neurotrophic factor gene polymorphisms in Japanese patients with sporadic Alzheimer's disease, Parkinson's disease, and multiple system atrophy
Auteurs : Masataka Nishimura [Japon] ; Sadako Kuno [Japon] ; Ryuji Kaji [Japon] ; Hideshi Kawakami [Japon]Source :
- Movement Disorders [ 0885-3185 ] ; 2005-08.
Descripteurs français
- Pascal (Inist)
- Wicri :
English descriptors
- KwdEn :
- Aged, Aged, 80 and over, Alzheimer Disease (genetics), Alzheimer disease, Alzheimer's disease, Brain derived neurotrophic factor, Brain-Derived Neurotrophic Factor (genetics), Cysteine (genetics), Female, Genetic Predisposition to Disease, Human, Humans, Japan (ethnology), Japanese, Male, Methionine (genetics), Middle Aged, Multiple System Atrophy (genetics), Multiple system atrophy, Nervous system diseases, Parkinson Disease (genetics), Parkinson disease, Parkinson's disease, Polymorphism, Polymorphism, Genetic, Sporadic, Threonine (genetics), Valine (genetics), brain‐derived neurotrophic factor, multiple system atrophy, polymorphism.
- MESH :
- chemical , genetics : Brain-Derived Neurotrophic Factor, Cysteine, Methionine, Threonine, Valine.
- geographic , ethnology : Japan.
- genetics : Alzheimer Disease, Multiple System Atrophy, Parkinson Disease.
- Aged, Aged, 80 and over, Female, Genetic Predisposition to Disease, Humans, Male, Middle Aged, Polymorphism, Genetic.
Abstract
We studied two genetic polymorphisms (240C/T and 480G/A) of the brain‐derived neurotrophic factor (BDNF) gene in Japanese patients with Alzheimer's disease (AD, n = 172), Parkinson's disease (PD, n = 327), and multiple system atrophy (MSA, n = 122), as well as controls (n = 275). The distribution of the 240 C/T polymorphism was significantly different between AD patients and controls, whereas there was no difference in the genotype of the two polymorphisms between MSA and controls or between PD and controls. Our data suggest that BDNF might play a role in AD. © 2005 Movement Disorder Society
Url:
DOI: 10.1002/mds.20491
Affiliations:
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2005-08">2005-08</date><biblScope unit="vol">20</biblScope><biblScope unit="issue">8</biblScope><biblScope unit="page" from="1031">1031</biblScope><biblScope unit="page" to="1033">1033</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">2EBC70499346F752745021DECA0A22B9E2EC2039</idno><idno type="DOI">10.1002/mds.20491</idno><idno type="ArticleID">MDS20491</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Alzheimer Disease (genetics)</term><term>Alzheimer disease</term><term>Alzheimer's disease</term><term>Brain derived neurotrophic factor</term><term>Brain-Derived Neurotrophic Factor (genetics)</term><term>Cysteine (genetics)</term><term>Female</term><term>Genetic Predisposition to Disease</term><term>Human</term><term>Humans</term><term>Japan (ethnology)</term><term>Japanese</term><term>Male</term><term>Methionine (genetics)</term><term>Middle Aged</term><term>Multiple System Atrophy (genetics)</term><term>Multiple system atrophy</term><term>Nervous system diseases</term><term>Parkinson Disease (genetics)</term><term>Parkinson disease</term><term>Parkinson's disease</term><term>Polymorphism</term><term>Polymorphism, Genetic</term><term>Sporadic</term><term>Threonine (genetics)</term><term>Valine (genetics)</term><term>brain‐derived neurotrophic factor</term><term>multiple system atrophy</term><term>polymorphism</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Brain-Derived Neurotrophic Factor</term><term>Cysteine</term><term>Methionine</term><term>Threonine</term><term>Valine</term></keywords><keywords scheme="MESH" type="geographic" qualifier="ethnology" xml:lang="en"><term>Japan</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Alzheimer Disease</term><term>Multiple System Atrophy</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Female</term><term>Genetic Predisposition to Disease</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Polymorphism, Genetic</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Atrophie multisystématisée</term><term>Démence Alzheimer</term><term>Facteur BDNF</term><term>Homme</term><term>Japonais</term><term>Parkinson maladie</term><term>Polymorphisme</term><term>Sporadique</term><term>Système nerveux pathologie</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Japon</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We studied two genetic polymorphisms (240C/T and 480G/A) of the brain‐derived neurotrophic factor (BDNF) gene in Japanese patients with Alzheimer's disease (AD, n = 172), Parkinson's disease (PD, n = 327), and multiple system atrophy (MSA, n = 122), as well as controls (n = 275). The distribution of the 240 C/T polymorphism was significantly different between AD patients and controls, whereas there was no difference in the genotype of the two polymorphisms between MSA and controls or between PD and controls. Our data suggest that BDNF might play a role in AD. © 2005 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Japon</li></country><settlement><li>Tokyo</li></settlement></list><tree><country name="Japon"><noRegion><name sortKey="Nishimura, Masataka" sort="Nishimura, Masataka" uniqKey="Nishimura M" first="Masataka" last="Nishimura">Masataka Nishimura</name></noRegion><name sortKey="Kaji, Ryuji" sort="Kaji, Ryuji" uniqKey="Kaji R" first="Ryuji" last="Kaji">Ryuji Kaji</name><name sortKey="Kawakami, Hideshi" sort="Kawakami, Hideshi" uniqKey="Kawakami H" first="Hideshi" last="Kawakami">Hideshi Kawakami</name><name sortKey="Kuno, Sadako" sort="Kuno, Sadako" uniqKey="Kuno S" first="Sadako" last="Kuno">Sadako Kuno</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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